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KMID : 0624620160490100554
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BMB Reports
2016 Volume.49 No. 10 p.554 ~ p.559
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Mycobacterium abscessus D-alanyl-D-alanine dipeptidase induces the maturation of dendritic cells and promotes Th1-biased immunity
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Lee Seung-Jun
Jang Jong-Hwa
Yoon Gun-Young
Kang Da-Rae
Park Hee-Jo
Shin Sung-Jae
Han Hee-Dong
Kang Tae-Heung
Park Won-Sun
Yoon Young-Kyung
Soh Byoung-Yul
Jung In-Duk
Park Yeong-Min
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Abstract
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Mycobacterium abscessus, a member of the group of non-tuberculous mycobacteria, has been identified as an emerging pulmonary pathogen in humans. However, little is known about the protective immune response of antigenpresenting cells, such as dendritic cells (DCs), which guard against M. abscessus infection. The M. abscessus gene MAB1843 encodes D-alanyl-D-alanine dipeptidase, which catalyzes the hydrolysis of D-alanyl-D-alanine dipeptide. We investigated whether MAB1843 is able to interact with DCs to enhance the effectiveness of the host's immune response. MAB1843 was found to induce DC maturation via toll-like receptor 4 and its downstream signaling pathways, such as the mitogen-activated protein kinase and nuclear factor kappa B pathways. In addition, MAB1843-treated DCs stimulated the proliferation of T cells and promoted Th1 polarization. Our results indicate that MAB1843 could potentially regulate the immune response to M. abscessus, making it important in the development of an effective vaccine against this mycobacterium.
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KEYWORD
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Dendritic cells, MAB1843, MAPK, Mycobacterium abscessus, Th1 polarization
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